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Birkhäuser Advances in Infectious Diseases Ser.: Replicating Vaccines : A New Generation by Philip R. Dormitzer (2010, Hardcover)

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Product Identifiers

Publisher
Springer Basel A&G
ISBN-10
3034602766
ISBN-13
9783034602761
eBay Product ID (ePID)
99693898

Product Key Features

Number of Pages
Xiii, 447 Pages
Publication Name
Replicating Vaccines : a New Generation
Language
English
Publication Year
2010
Subject
Immunology, Microbiology, Preventive Medicine, Infectious Diseases, Pharmacology
Type
Textbook
Author
Philip R. Dormitzer
Subject Area
Medical
Series
Birkhäuser Advances in Infectious Diseases Ser.
Format
Hardcover

Dimensions

Item Weight
33.2 Oz
Item Length
9.3 in
Item Width
6.1 in

Additional Product Features

Intended Audience
Scholarly & Professional
Dewey Edition
23
Reviews
From the reviews: "This book introduces the current thinking on rational attenuation and this important theme runs through the book, tying the chapters together very nicely. ... Given the renaissance in vaccinology this is a timely volume which ... makes judicious use of selected examples to highlight key aspects of this burgeoning field. This book is both a useful primer for students and a thought-provoking read for researchers in this field." (Paul Duprex, Microbiology Today, November, 2011), From the reviews:This book introduces the current thinking on rational attenuation and this important theme runs through the book, tying the chapters together very nicely. â€¦ Given the renaissance in vaccinology this is a timely volume which â€¦ makes judicious use of selected examples to highlight key aspects of this burgeoning field. This book is both a useful primer for students and a thought-provoking read for researchers in this field. (Paul Duprex, Microbiology Today, November, 2011)
Number of Volumes
1 vol.
Illustrated
Yes
Dewey Decimal
615.372
Table Of Content
SECTION 1: Today's Live Attenuated Vaccines.- Live Vaccines and their Role in Modern Vaccinology.- Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster.- Classical Live Viral Vaccines.- SECTION 2: Genetically Attenuated Micro-Organisms as Vaccines.- Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus.- Live Attenuated Shigella Vaccines. Is encouraging good enough'.- New generation BCG vaccines.- SECTION 3: Manipulating Host-Pathogen Interactions to Make Vaccines.- Basic Science Paves the Way to Novel Safe and Effective Pestivirus Vaccines.- Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation Approaches.- An Attenuated Herpes implex Virus 1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell to Cell and Neuronal Spread.- RSV Deletion Mutant - Innate Immunity.- Live Attenuated Cholera Vaccines: Flagella and Reactogenicity.- SECTION 4: New Types of Replicating Vaccines.- Replication-defective Herpes simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors.- Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines.- Application of Cleavage Activation Mutants of Influenza Virus as Live Vaccines.- Alphavirus Particle-based Vaccine Vectors.- Recombinant, Chimeric, Live, Attenuated Vaccines against Flaviviruses and Alphaviruses.
Synopsis
Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines., Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines.This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.
LC Classification Number
QR46

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