bulksupplements Agmatine Sulfate - Nitric Oxide - Pre Workout Powder What Is Agmatine Sulfate? Agmatine sulfate is an aminoguanidine, also known as (4-aminobutyl) guanidine, and was originally discovered in 1910. It is created naturally from the amino acid, arginine, and plays a role in several different body functions including acting as a neuromodulator and neurotransmitter. It also plays an important role in nitric oxide synthesis, which may promote healthy circulation and muscle pump during exercise. Agmatine Sulfate Benefits Agmatine sulfate is best known for its ability to help build muscle. When used in conjunction with weight lifting and resistance exercises, agmatine may help fuel muscle growth through a few different mechanisms. It stimulates the production of luteinizing hormone which may positively impact testosterone levels.