Imagen 1 de 1
Foto genérica
Imagen 1 de 1
Foto genérica
Pharmacology-Research, Safety Testing and Regulation Ser.: Pharmacological Guide to Metformin by Natalie Lajoie (2019, Trade Paperback)
Great Book Prices Store (345996)
97,2% de votos positivos
Precio:
USD158,03
Aproximadamente134,54 EUR
+ USD20,79 de envío
Devoluciones:
Estado:
It is the most commonly prescribed and utilized oral antidiabetic drug worldwide.
- ¡Cómpralo ya!Pharmacological Guide to Metformin, Paperback by Lajoie, Natalie (EDT), Brand...
Oops! Looks like we're having trouble connecting to our server.
Refresh your browser window to try again.
Acerca de este artículo
Product Identifiers
PublisherNOVA Science Publishers, Incorporated
ISBN-101536166340
ISBN-139781536166347
eBay Product ID (ePID)20038629372
Product Key Features
Number of Pages248 Pages
Publication NamePharmacological Guide to Metformin
LanguageEnglish
Publication Year2019
SubjectLife Sciences / Anatomy & Physiology (See Also Life Sciences / Human Anatomy & Physiology), Pharmacology
TypeTextbook
Subject AreaScience, Medical
AuthorNatalie Lajoie
SeriesPharmacology-Research, Safety Testing and Regulation Ser.
FormatTrade Paperback
Dimensions
Item Weight17.1 Oz
Additional Product Features
LCCN2019-954056
TitleLeadingThe
IllustratedYes
Table Of ContentPreface; The Pharmacogenetics of Metformin; Physicochemical and Pharmacokinetic Properties of Metformin Hydrochloride; Metformin: Who Are Suitable Patients?; Metformin Effects in Cancer Models; The Therapeutic Potential of Metformin in Breast and Ovarian Cancer; Index.
SynopsisAlmost six decades after its discovery, metformin still remains the gold standard drug for the management of type 2 diabetes mellitus, owing to its euglycemic property and cost-effectiveness. It is the most commonly prescribed and utilised oral antidiabetic drug worldwide. However, no two persons with the same phenotypical characteristics, such as age, gender, body weight and others, tend to respond similarly to equivalent doses of metformin. As such, the book first focuses on the various genetic polymorphisms that influence the therapeutic effects of metformin. Physicochemical, pharmacological, and pharmacokinetic properties of metformin will also be reviewed. The side effects of this drug can be dangerous. Metformin-induced lactic acidosis is a lethal disorder. The first significant deviation is gastrointestinal tract involvement. Common infection or the effect of metformin itself causes vomiting and diarrhoea, with subsequent hypovolemia causing pre-renal acute kidney injury, which in turn raises metformin levels up to toxic values. Development of kidney failure is often unexpected and fast. Following this, the authors explore the differences between healthy and cancer cells and how this may influence the metformin effect on these cells. In conclusion, the molecular mechanisms underlying the anticancer effects of metformin in breast and ovarian cancers are summarised, and the potential anticancer applications of metformin-based combinatorial chemotherapy are discussed., Almost six decades after its discovery, metformin still remains the gold standard drug for the management of type 2 diabetes mellitus, owing to its euglycemic property and cost-effectiveness. It is the most commonly prescribed and utilized oral antidiabetic drug worldwide. However, no two persons with the same phenotypical characteristics, such as age, gender, body weight and others, tend to respond similarly to equivalent doses of metformin. As such, The Pharmacological Guide to Metformin first focuses on the various genetic polymorphisms that influence the therapeutic effects of metformin.Physicochemical, pharmacological, and pharmacokinetic properties of metformin will also be reviewed.The side effects of this drug can be dangerous. Metformin-induced lactic acidosis is a lethal disorder. The first significant deviation is gastrointestinal tract involvement. Common infection or the effect of metformin itself causes vomiting and diarrhea, with subsequent hypovolemia causing pre-renal acute kidney injury, which in turn raises metformin levels up to toxic values. Development of kidney failure is often unexpected and fast.Following this, the authors explore the differences between healthy and cancer cells and how this may influence the metformin effect on these cells.In conclusion, the molecular mechanisms underlying the anticancer effects of metformin in breast and ovarian cancers are summarized, and the potential anticancer applications of metformin-based combinatorial chemotherapy are discussed.
LC Classification NumberQP801.M39P43 2020
