Characterization of Protein Therapeutics using Mass Spectrometry, Chen, 97814419

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Características del artículo

Estado
En buen estado: Libro que se ha leído pero que está en buen estado. Daños mínimos en la tapa, ...
ISBN
9781441978615
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Product Identifiers

Publisher
Springer
ISBN-10
1441978615
ISBN-13
9781441978615
eBay Product ID (ePID)
112079435

Product Key Features

Number of Pages
X, 404 Pages
Publication Name
Characterization of Protein Therapeutics Using Mass Spectrometry
Language
English
Publication Year
2013
Subject
Spectroscopy & Spectrum Analysis, Life Sciences / Molecular Biology, Chemistry / Analytic, Pharmacology, Chemistry / Organic
Type
Textbook
Subject Area
Science, Medical
Author
Guodong Chen
Format
Hardcover

Dimensions

Item Weight
27.8 Oz
Item Length
9.3 in
Item Width
6.1 in

Additional Product Features

Intended Audience
Scholarly & Professional
Dewey Edition
23
Number of Volumes
1 vol.
Illustrated
Yes
Dewey Decimal
615.3
Table Of Content
Characterization of Protein Therapeutics by Mass Spectrometry: Recent Developments and Future Directions.- The Use of Mass Spectrometry to Characterize the Metabolism of Peptide Therapeutics.- Quantitative Analysis of Biologics Using Mass Spectrometry.- Maximizing Structural Information from Whole Protein Tandem Mass Spectrometry.- Disulfide Linkages of an Albumin Fusion Protein.- Detailed Structural Characterization of Monoclonal Antibodies.- Application of Protein Mass Spectrometry in Impurity and Degradant Characterization.- Mass Spectrometry Methods to Analyze Higher Order Structure of Protein Therapeutics by Chemical Footprinting.- Aglycosylations Alters Protein Conformation in Antibodies Engineered with Specific Effector Functions Using HDX-MS.- Characterizing Biotherapeutic Protein 3D Structures by Electrospray Ion-Mobility Mass Spectrometry.- Oxford University, Characterization of Assemblies of Proteins by Mass Spectrometry.
Synopsis
This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development., 1 Introduction to Protein Mass Spectrometry 2 Quantitative Analysis of Therapeutic and Endogenous Peptides Using LC/MS/MS Methods 3 The Development and Implementation of LC/MS-based Bioanalytical Methods for the Quantification of Protein Therapeutics in Drug 4 Post-Translationally Modified Proteins: Glycosylation and Disulfide Bond Formation 5 Mass Spectrometric Characterization in Protein Therapeutics Discovery 6 Molecular Variants Characterization in Protein Therapeutics Development 7 Mass Spectrometry of Antibody-Drug Conjugates in Plasma and Tissue in Drug Development 8 Hydrogen / Deuterium Exchange Mass Spectrometry for Protein Higher Order Structure Characterization 9 Fast Photochemical Oxidation of Proteins for Structural Characterization 10 Applications of Ion Mobility Mass Spectrometry for Characterization of Protein Therapeutics, This volume provides an overview of mass spectrometry techniques for the analysis of protein therapeutics, structural identification strategies, and quantitative approaches. Studies involving the characterization of process-related protein drug impurities are also discussed.
LC Classification Number
QD96.M3

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