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Handbook of Pharmaceutical Salts: Properties, Selection, and Use By Stahl. 2 Edt
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N.º de artículo de eBay:226896754225
Última actualización el 06 ago 2025 02:03:24 H.EspVer todas las actualizacionesVer todas las actualizaciones
Características del artículo
- Estado
- Educational Level
- Adult & Further Education
- ISBN
- 9783906390512
Acerca de este producto
Product Identifiers
Publisher
Wiley & Sons, Incorporated, John
ISBN-10
3906390519
ISBN-13
9783906390512
eBay Product ID (ePID)
108944970
Product Key Features
Number of Pages
388 Pages
Publication Name
Pharmaceutical Salts : Properties, Selection, and Use
Language
English
Subject
Chemistry / Clinical, Chemistry / General
Publication Year
2011
Type
Handbook
Subject Area
Science
Format
Hardcover
Dimensions
Item Height
1.1 in
Item Weight
43.3 Oz
Item Length
9.5 in
Item Width
6.9 in
Additional Product Features
Edition Number
2
Intended Audience
Scholarly & Professional
Reviews
"... the editors have produced a rare commodity, a body of knowledge on an important area, summarized in single volume. In a nutshell, this long-overdue volume belongs on the personal shelf of every pharmaceutical scientist working with new chemical entities." (Pharmaceutical Development and Technology), "...the editors have produced a rare commodity, a body of knowledge on an important area, summarized in single volume.In a nutshell, this long-overdue volume belongs on the personal shelf of every pharmaceutical scientist working with new chemical entities." (Pharmaceutical Development and Technology)
Dewey Edition
22
Illustrated
Yes
Dewey Decimal
615.19
Edition Description
Handbook (Instructor's)
Table Of Content
Introduction ( Camille G. Wermuth and P. Heinrich Stahl ). Chapter 1. The Physicochemical Background: Fundamentals of Ionic Equilibria ( Michael B. Maurin, David J. W. Grant, and P. Heinrich Stahl ). Chapter 2. Solubility and Dissolution of Weak Acids, Bases, and Salts ( Madhu Pudipeddi, Abu T. M. Serajuddin, David J. W. Grant, and P. Heinrich Stahl ). Chapter 3. Evaluation of Solid-State Properties of Salts ( Danielle Giron and David J. W. Grant ). Chapter 4. Pharmaceutical Aspects of the API Salt Form ( P. Heinrich Stahl and Finlay S. Skinner ). Chapter 5. Biological Effects of the API Salt Form ( Friedlieb Pfannkuch, Harald Rettig, and P. Heinrich Stahl ). Chapter 6. Salt-Selection Strategies ( Abu T. M. Serajuddin and Madhu Pudipe ddi). Chapter 7. A Procedure for Salt Selection and Optimization (Michael J. Bowker). Chapter 8. High-Throughput Strategies and Techniques for Salt Screening ( Nicole Wyttenbach, Bertrand Sutter, and Pirmin Hidber ). Chapter 9. Large-Scale Aspects of API Salt Manufacture ( Piotr H. Karpioski ). Chapter 10. Patent Aspects of API Salt Formation ( Hans-Günther Foraita ). Chapter 11. Regulatory Aspects of API Salts ( Maria Arfwedson and Alan Chalmers, Jun-ichi Kondo and P. Heinrich Stahl, and Mansoor A. Khan and Vilayat A. Sayeed ). Chapter 12. Selected Procedures for the Preparation of Pharmaceutically Acceptable Salts ( Camille G. Wermuth and P. Heinrich Stahl ). Chapter 13. Monographs on Acids and Bases ( P. Heinrich Stahl and Camille G. Wer muth). Appendix ( P. Heinrich Stahl ). Subject-Index. Substance-Index.
Synopsis
In dieser zweiten, überarbeiteten Auflage des sehr erfolgreichen Bandes über pharmazeutisch aktive Salze geht es um die Auswahl geeigneter Salzformen für die Vermarktung neuer Wirkstoffe. Dazu wird die Präparation der einzelnen Salze beschrieben, der Wirkstofftransport im Organismus verfolgt und die Wirksamkeit der Salze diskutiert. Neben sehr umfangreichen Hinweisen für die praktische Arbeit kommen aber auch die theoretischen Grundlagen nicht zu kurz. Die Beiträge stammen von einem hochklassigen, interdisziplinär orientierten Autorenteam., In this second, revised edition, authors from academia and industry present the theoretical foundations plus a wealth of practical experience in the choice of pharmaceutically active salts, taking great care to address every conceivable aspect., The first edition of this handbook successfully filled a gap by collating, for the first time, in one volume the scientific literature and industrial experience on the preparation, selection, and use of salts of active pharmaceutical ingredients (API), examining the opportunities for increased efficacy and improved drug delivery provided by the selection of an optimal salt. Updated and extended, the second, revised edition of this comprehensive resource is designed to meet the increasing interest in the topic. It should be in the library of every pharmaceutical company Organic Process Research and Development Journal A rare commodity, a body of knowledge on an important area, summarized in a single volume. This long overdue volume belongs on the personal shelf of every pharmaceutical scientist. Pharmaceutical Development and Technology, The first edition of this handbook was a tremendous success, collating the scientific literature on this topic that had otherwise been rather limited and scattered throughout numerous journals and patents. The result was a comprehensive resource that addresses the preparation, selection, and use of pharmaceutically active salts, examining the opportunities for increased efficacy and improved drug delivery provided by the selection of an optimal salt. This second, revised edition is designed to meet the continued interest in both the topic and the book. Altogether, the contributions to this book by international team of authors from academia and pharmaceutical industry reflect the multidisciplinary nature of the science involved in selection of suitable salt forms for new drug products. They present the necessary theoretical foundations as well as a wealth of detailed practical experience in the choice of pharmaceutically active salts, taking great care to address every conceivable aspect of the preparation of pharmaceutical salts. An introductory chapter presents a concise review of the various objectives in the pursuit of pharmaceutically active salts, followed by the theoretical background of salt formation. There then follow chapters on the practice of salt formation in an industrial R&D environment, as well as regulatory and patent issues. Practical examples for the practitioners at the lab bench are provided, before the book concludes with a comprehensive annotated compilation of the individual salt-forming acids and bases with their relevant properties, followed by an appendix containing tables with the acids and bases sorted alphabetically and by pKa, supplemented with other useful facts and data. An essential reference for students of medicinal and pharmaceutical chemistry, and an indispensable handbook for R&D chemists, analytical chemists, biologists, development pharmacists, regulatory and patent specialists, and medicinal scientists engaged in preclinical development of drugs. In addition, this comprehensive and up-to-date guide is an instructive companion for all scientists involved in the research and development of drugs and, in particular, of pharmaceutical dosage forms.
LC Classification Number
RS403
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