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Introduction to Macromolecular Binding Equilibria by Charles P. Woodbury (2007,
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Ubicado en: Rockville, Maryland, Estados Unidos
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Entrega prevista entre el vie. 5 sep. y el mié. 10 sep. a 94104
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N.º de artículo de eBay:197268572585
Última actualización el 08 jul 2025 07:59:20 H.EspVer todas las actualizacionesVer todas las actualizaciones
Características del artículo
- Estado
- ISBN
- 9781420052985
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Product Identifiers
Publisher
CRC Press LLC
ISBN-10
1420052985
ISBN-13
9781420052985
eBay Product ID (ePID)
57039728
Product Key Features
Number of Pages
260 Pages
Language
English
Publication Name
Introduction to Macromolecular Binding Equilibria
Subject
Physics / General, Chemistry / General
Publication Year
2007
Type
Textbook
Subject Area
Science
Format
Hardcover
Dimensions
Item Height
0.9 in
Item Weight
18.4 Oz
Item Length
9.3 in
Item Width
6.5 in
Additional Product Features
Intended Audience
College Audience
LCCN
2007-020733
Dewey Edition
22
Illustrated
Yes
Dewey Decimal
572.33
Table Of Content
Binding sites. Binding isotherms. Binding linkage, binding competition, and multiple ligand species. Cooperativity. Binding to lattices of sites. Choosing a method and analyzing the data. Appendix: The sequence-generating function method. Index
Synopsis
This compact, graduate-level text focuses on a key area of biophysical chemistry. Introduction to Macromolecular Binding starts with a description of the features of binding sites for small molecules and then presents a discussion of the formulation of binding isotherms for simple mathematical models. The book addresses special problems of describing isotherms for linear polymers and examines the complications of binding cooperativity and thermodynamic linkage interactions among multiple ligands. Important aspects of experimental designs are highlighted along with methods for model-free analysis of data to reveal the binding isotherm. The author also covers ligand binding to planar arrays of sites., Macromolecules in the body form noncovalent associations, such as DNA-protein or protein-protein complexes, that control and regulate numerous cellular functions. Understanding how changes in the concentration and conformation of these macromolecules can trigger physiological responses is essential for researchers developing drug therapies to treat diseases affected by these imbalances. Introduction to Macromolecular Binding Equilibria gives students in medicinal chemistry, pharmaceuticals, and bioengineering the necessary background in biophysical chemistry for research applications in drug discovery and development. Building upon a fundamental knowledge of calculus and physical chemistry, this compact, graduate-level text prepares students for advanced work in solution thermodynamics and binding phenomena and applying methods in this book to their own research. This book describes the underlying theory of binding phenomena and explains how to apply the binding polynomial approach for building models and interpreting data. It also covers practical considerations for setting up binding experiments and describes how to obtain true thermodynamic isotherms unbiased by model assumption via model-free analysis of binding data.
LC Classification Number
QP517.B42W66 2008
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